High Quality MALDI Imaging of Proteins and Peptides in Small Rodent Organ Tissues
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چکیده
New developments in MALDI instrumentation, laser technology and sample preparation techniques have turned research-style MALDI imaging of proteins and peptides into a routine technique. To evaluate the potential of MALDI imaging with regard to the resolution and information content of the images that can be obtained, biological systems with well-defined structures on both the macroscopic and microscopic level are helpful. Organs of small mammals, such as the brain, kidney, testis, pancreas and spleen of mice or rats have these desired properties and are easily accessible. For these reasons, they are preferred samples for MALDI imaging method development. In this application note we present the current state-of-the-art in MALDI imaging of rodent organs.
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